During the platelet donation process, white blood cells are filtered from platelet products using a leukoreduction system (LRS) since white cells can cause a variety of transfusion reactions and other issues. Blood centers used to discard these filtered cells, but by gathering available groups and collecting them into an LRS chamber, waste of blood byproducts is minimized and this powerful LRS chamber material can be utilized for research.
The LRS chamber itself is a conical-shaped chamber that uses saturated, fluidized, particle bed filtration technology to remove WBCs from PLTs and be a valuable and convenient source of viable human peripheral blood mononuclear cell population and could replace standard buffy coat preparations for research applications.
With over 1 billion cells in each chamber, the collection is extremely valuable to researchers, as it allows them to conduct more expansive experiments. Leukoreductions now play a key role advancing discoveries related to a variety of diseases and ailments, including cancer.
Leukoreduction system chambers are an efficient, valid, and economic source of functional monocyte-derived dendritic cells and lymphocytes, and are a vital source of Viable Human Peripheral Blood Mononuclear Cells and T cells.